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What is a VDR?

Virtual Data Rooms (VDRs) are safe and reliable methods to access confidential documents during business transactions. VDRs can be used to perform due diligence in mergers and acquisitions. They also assist companies organize important documents and share them with investors and other stakeholders. VDRs can also be used to store and manage invoices, contracts and other documents that are required for legal purposes like estate planning and litigation.

Members should be aware of the procedures and equipment installed on their vessels equipped with VDR/SVDR. It is also recommended to take the opportunity to upgrade and replace those that may be outdated or that are not in compliance with the minimum safety standards.

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes control the production of proteins that are involved in a myriad of physiological processes.

The VDR is found in neurons, as well as a subset glial cells, which form part of the brain. In the primary hippocampal culture of rat there was immunoreactivity for the VDR was detected in oligodendrocytes. The VDR is also found in human neuroblastoma and astrocytes. The treatment of leukemia cells from HL-60 by 1,25(OH2)2D3 led to monocyte-like differentiation and increased VDR levels. This effect was counteracted by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.

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